In Book IV of the Metamorphoses, Ovid recounts the tale of the young and beautiful Andromeda, daughter of the Aethiopian king Cepheus and Cassiopeia. Boasting that Andromeda is more beautiful than the Nereids, Cassiopeia angers Neptune, who, in revenge, sends a monster to ravage the coast of Aethiopia. Told that the only way to save their country is to sacrifice their daughter to the creature, Andromeda’s parents chain her to a rock by the sea. The hero Perseus, son of Jupiter and Danaë, sees Andromeda while flying over Aethiopia and falls in love with her. He asks her parents for permission to marry her if he is able to save her; he subsequently kills the sea monster and rescues Andromeda.
On one of the Archinto ceilings, Tiepolo represented this subject surrounded by eight smaller mythological scenes. The fresco was set in elaborate stucco decorations, possibly created by a team of stucco workers and in a style close to that of Giovan Battista Aliprandi (1665–1720), who was responsible for introducing the French taste for stucco to Milan.